Honey has antioxidant and anti-inflammatory properties. It is used to treat recalcitrant wounds, ulcers, burns and pressure sores. Understanding the mechanisms by which honey helps healing will assist with the identification and handling of honey for use in healthcare. With concern over the overuse of antibiotics, alternative treatments that can heal and fight bacterial infections are gaining attention. Understanding how honey affords its protection and additive healing power may well provide much needed new healthcare treatments.